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KMID : 0365819740140020245
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Journal of Pusan Medical College
1974 Volume.14 No. 2 p.245 ~ p.256
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Effects of Several Anesthetics on the Gastric Secretion and Ulcer Formation in Rats
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Abstract
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The author studied the effects of various general anesthetics and premedicants on gastric secretion and ulcer formation in rats and obtained the following results:
1. The response of gastric secretion under light general anesthesia using diethyl ether, methoxyflurane, ketamine and thiopental when used to anesthetize rats before pyloric ligation did not affect gastric secretion, but diethyl ether under high partial pressure for a shorter duration and halothane alone increased gastric secretion. Light anesthesia with chloroform and light anesthesia with diethyl ether for longer periods depressed gastric secretion.
2. The response of gastric secretion under deep general anesthesia such as diethyl ether, methoxyflurane, ketamine and thiopental did rot induce any change in gastric secretion when used as light anesthesia. When used for prolonged periods as deep anesthesia, they depressed gastric secretion significantly.
3. Ulcer formation, as determined by the Shay technique, was not influenced by diethyl ether, ketamine, halothane and methoxyflurane even though the rats were anesthetized with deep anesthesia by these anesthetics. When anesthetized with light anesthesia by chloroform or deep anesthesia by thiopental, the ulcer index was markedly decreased, indicating an inhibitory effect of gastric secretion by these anesthetics.
4. Even though the gastric secretion as measured by volume, free acid and pepsin were inhibited by all of the following: A. Light anesthesia with diethyl ether for extended anesthetic time, B. Light anesthesia with chloroform or, C. Deep anesthesia with methoxyflurane, there was a marked reversal of this inhibition in the post anesthetic period by the injection of insulin 0. 75 units intravenously. Premeditation with 1 mg/100 grams of body weight of phenobarbital or 0.2 mg/100 grams of body weight of diazepam did not effect the above reversal by insulin; however, premeditation with 2 mg/100 grams of body weight of phenobarbital did inhibit gastric secretion in the post anesthetic period when 0. 75 units of insulin was injected intravenously.
5. Diethyl ether, halothane or diazepam did not influence the formation of restraint stress ulcer in rats, but deep anesthesia with thiopental and 1 mg/100 grams of body weight of phenobarbital inhibited ulcer formation moderately. Chloroform and 2 mg/100 grams of body weight of phenobarbital markedly depressed the ulcer index.
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